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lanreotide  (Toronto Research Chemicals)


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    Structured Review

    Toronto Research Chemicals lanreotide
    Lanreotide, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/lanreotide/Lanreotide+Acetate/pm40690368-163-6-10
    Average 93 stars, based on 1 article reviews
    lanreotide - by Bioz Stars, 2026-09
    93/100 stars

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    Related Articles

    other:

    Article Title: Investigating the Interactions of a Cyclic Peptide Hormone Somatostatin and Its Derivatives on Amyloid-Beta Aggregation.
    Article Snippet: We investigated the effects of cyclic peptides somatostatin, its isomer D-Trp8-somatostatin, and marketed somatostatin derivatives octreotide and lanreotide on Aβ42 aggregation and cytotoxicity in mouse hippocampal HT22 cells.. The aggregation kinetic studies show that all the cyclic peptides were able to reduce Aβ42 fibrillogenesis at 1, 5, 10, and 25 μM.. The native cyclic peptide somatostatin exhibited superior inhibition compared to other cyclic peptides (91% inhibition at 25 μM) and exhibited greater inhibition compared to the reference agent orange G (86% inhibition at 25 μM), whereas the corresponding isomer D-Trp8-somatostatin exhibited 74% inhibition at 25 μM.



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    Image Search Results


    On the top is the sequence of the native somatostatin peptide. The blue sequence in somatostatin represents a key pharmacophore in somatostatin, responsible for receptor binding. In somatostatin analogues, lysine (K) is conserved, while tryptophan is replaced with its stereoisomers in octreotide, lanreotide, vapreotide, and pasireotide. Phenylalanine is substituted with tyrosine, which has an additional hydroxyl group, and threonine is replaced with a more hydrophobic amino acid, such as valine, in lanreotide and vapreotide. Pasireotide incorporates the highest number of unnatural amino acids. In this analogue, cyclization occurs between the N- and C-terminal ends, while in octreotide, lanreotide, and vapreotide, cyclization involves the side chains of cysteine residues, similar to native somatostatin.

    Journal: Chemical Reviews

    Article Title: Advances in Peptidomimetics for Next-Generation Therapeutics: Strategies, Modifications, and Applications

    doi: 10.1021/acs.chemrev.4c00989

    Figure Lengend Snippet: On the top is the sequence of the native somatostatin peptide. The blue sequence in somatostatin represents a key pharmacophore in somatostatin, responsible for receptor binding. In somatostatin analogues, lysine (K) is conserved, while tryptophan is replaced with its stereoisomers in octreotide, lanreotide, vapreotide, and pasireotide. Phenylalanine is substituted with tyrosine, which has an additional hydroxyl group, and threonine is replaced with a more hydrophobic amino acid, such as valine, in lanreotide and vapreotide. Pasireotide incorporates the highest number of unnatural amino acids. In this analogue, cyclization occurs between the N- and C-terminal ends, while in octreotide, lanreotide, and vapreotide, cyclization involves the side chains of cysteine residues, similar to native somatostatin.

    Article Snippet: lanreotide , Somatuline , somatostatin analogue (SSA) , 2007 , Ipsen, Globopharm, Tercica , acromegaly, neuroendocrine tumors, and conditions with excess hormone secretion , SC.

    Techniques: Sequencing, Binding Assay, Analogues

    On the top is the sequence of the native somatostatin peptide. The blue sequence in somatostatin represents a key pharmacophore in somatostatin, responsible for receptor binding. In somatostatin analogues, lysine (K) is conserved, while tryptophan is replaced with its stereoisomers in octreotide, lanreotide, vapreotide, and pasireotide. Phenylalanine is substituted with tyrosine, which has an additional hydroxyl group, and threonine is replaced with a more hydrophobic amino acid, such as valine, in lanreotide and vapreotide. Pasireotide incorporates the highest number of unnatural amino acids. In this analogue, cyclization occurs between the N- and C-terminal ends, while in octreotide, lanreotide, and vapreotide, cyclization involves the side chains of cysteine residues, similar to native somatostatin.

    Journal: Chemical Reviews

    Article Title: Advances in Peptidomimetics for Next-Generation Therapeutics: Strategies, Modifications, and Applications

    doi: 10.1021/acs.chemrev.4c00989

    Figure Lengend Snippet: On the top is the sequence of the native somatostatin peptide. The blue sequence in somatostatin represents a key pharmacophore in somatostatin, responsible for receptor binding. In somatostatin analogues, lysine (K) is conserved, while tryptophan is replaced with its stereoisomers in octreotide, lanreotide, vapreotide, and pasireotide. Phenylalanine is substituted with tyrosine, which has an additional hydroxyl group, and threonine is replaced with a more hydrophobic amino acid, such as valine, in lanreotide and vapreotide. Pasireotide incorporates the highest number of unnatural amino acids. In this analogue, cyclization occurs between the N- and C-terminal ends, while in octreotide, lanreotide, and vapreotide, cyclization involves the side chains of cysteine residues, similar to native somatostatin.

    Article Snippet: lanreotide , Somatuline depot , somatostatin analogue (SSA) , 2007 , Ipsen , acromegaly, neuroendocrine tumors, and conditions with excess hormone secretion , SC.

    Techniques: Sequencing, Binding Assay, Analogues